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Brickellia atractyloides
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Brickellia atractyloides |
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Brickellia californica |
Brickellia californica
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Brickellia coulteri Pima Co., Santa Catalina Mts., 3000 ft., AZ, Arizona State University, College of Pharmacy, AZ |
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Brickellia floribunda
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Brickellia incana
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Brickellia
laciniata |
Brickellia laciniata
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Brickellia aff. microphylla Note: This appears to be a distinct variant in its broad low densely branched habit, and is not the same as that collected earlier (Spjut 14741).
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Brickellia microphylla
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Brickellia microphylla
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Brickellia oblongifolia
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Brickellia rusbyi |
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He J, E. M. Wijeratne, B. P. Bashyal, J. Zhan, C. J. Seliga, M. X. Liu, E. E. Pierson, L. S. Pierson 3rd, H. D. van Etten and A. A. Gunatilaka. 2004. Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants. J. Nat. Prod. 67(12): 1985–1991. “In a study to discover potential anticancer agents from rhizosphere fungi of Sonoran desert plants cytotoxic EtOAc extracts of four Aspergillus strains have been investigated. Two new metabolites, terrequinone A (1) and terrefuranone (2), along with Na-acetyl aszonalemin (LL-S490beta) (3) were isolated from As. terreus occurring in the rhizosphere of Ambrosia ambrosoides, whereas As. terreus inhabiting the rhizosphere of an unidentified Brickellia sp. afforded dehydrocurvularin (4), 11-methoxycurvularin (5), and 11-hydroxycurvularin (6). As. cervinus isolated from the rhizosphere of Anicasanthus thurberi contained two new compounds, 4R*,5S*-dihydroxy-3-methoxy-5-methylcyclohex-2-enone (7) and 6-methoxy-5(6)-dihydropenicillic acid (8), in addition to penicillic acid (9). Penicillic acid was also isolated from As. wentii occurring in the rhizosphere of Larrea tridentata. The structures of 1-9 were elucidated by spectroscopic methods and chemical derivatizations. Acetylation of 2 afforded 14-acetylterrefuranone (13) and 14-deoxy-13(14)-dehydroterrefuranone (14). Metabolites 1-9, the dienone 14, and 5(6)-dihydropenicillic acid (16) were evaluated for cytotoxicity in a panel of four human cancer cell lines and in normal human primary fibroblast cells. Compounds 4 and 5 displayed considerable cytotoxicity, whereas 1, 6, 9, and 14 were found to be moderately active, with 6 and 9 exhibiting selective cytotoxicity against cancer cell lines compared with the normal fibroblast cells.” Perez R. M., H. Cervantes, M. A. Zavala, J. Sanchez, S. Perez and C. Perez C. 2000. Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. Phytomedicine 7(1): 25–29. “Hypoglycemic activity-guided fractionation together with chemical analysis led to the isolation of one flavone (5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone) from the chloroform extract of the leaves of Brikkellia veronicaefolia. Identification was based on spectroscopic methods. The isolated flavone was tested for hypoglycemic activity in normal and alloxan-diabetic CD1 mice (25-30 g) were administered in doses of 10, 25 and 50 mg/kg body weight. The blood glucose levels were determined before and 1.5, 3, 4.5 and 24 hours after drug administration. The results showed that the flavone produces a significant hypoglycemic effect in normal as well as in diabetic mice. Comparison was made between the action of the flavone and a known hypoglycemic drug as tolbutamide (50 mg/kg). The flavone was found to be slow and less effective than tolbutamide.” Rosler K. H., R. S. Goodwin, T. J. Mabry, S. D. Varma and J. Norris. 1984. Flavonoids with anti-cataract activity from Brickellia arguta. J. Nat. Prod. 47(2): 316–319. “Six flavonoids were isolated from Brickellia arguta and identified using chemical and spectral methods. The isolation and spectral data of a new flavonoid, 6- methoxykaempferol 3-O-beta-D- robinobioside (3), are reported for the first time. Three of these flavonoids were tested and showed inhibition of rat lens aldose reductase.” |
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