World Botanical Associates Web Page
Prepared by Richard W. Spjut
Species with antitumor activity
Ipelearoside, active in WA, was reportedly isolated by Dhar from a sample of this species (Hartwell 1976).
Cao S., R. C.
Guza, J. H. Wisse, J. S. Miller, R. Evans and D. G. Kingston. 2005.
Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of
Ipomoea squamosa from the Suriname rainforest. J. Nat. Prod. 68:
“The new glycoresins, ipomoeassins A-E (1-5), have been
isolated from the leaves of Ipomoea squamosa. The structures were
elucidated by spectroscopic analyses and chemical transformations. The
absolute configurations of C-5 (ipomoeassins 3-5) and C-11 (ipomoeassins 1
and 2) were determined by their derivatives with (R)- and (S)-MPA. All the
isolates were active in the A2780 human ovarian cancer cell line assay,
and 4 showed the highest activity with an IC(50) value of 35 nM.”