|
Thamnosma montana
|
Thamnosma montana
|
|
Ahua, K.M., J. R. Ioset, A. Ransijn, J. Mauel, S. Mavi and K. Hostettmann. 2004. Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica. Phytochemistry. 65(7): 963–968. “Eight furanocoumarins, one coumarin and four acridone derivatives have been identified in the roots of Thamnosma rhodesica (Rutaceae). Rhodesiacridone, one of these acridone derivatives, is reported here for the first time. Its structure was elucidated by spectrometric methods including ESI-HR, EI, DCI mass spectrometry, 1H, 13C and 2D NMR experiments. This novel compound showed activities against the intracellular form of a human pathogen, the protozoan parasite Leishmania major. Two known acridone related compounds, gravacridonediol and 1-hydroxy-10-methylacridone, exhibited activities against the intracellular form of the same parasite and the fungus Cladosporium cucumerinum, respectively.” Chang P.T., G. A. Cordell, G. H. Aynilian, H. H. Fong and N. R. Farnsworth. Alkaloids and coumarins of Thamnosma montana. 1976. Lloydia 39: 134–140. “From the turpentine broom, Thamnosma montana, four alkaloids and three coumarins were isolated and characterized. Skimmianine (5), N-methyl-acridone (4) and 5-(3'-methyl-2',3'-dihydroxybutanyl)-8-methoxypsoralen (1) were obtained previously from T. montana. Robustine (2) is reported from a Thamnosma species for the first time and acridone (6), thamnosmonin (9), and thamontanin (14) are reported from a natural source for the first time. Evidence for the structures of the new isolates is presented.” Crosby, D. G. 1954. The Structures of Phytotoxic Compounds from Thamnosma montana. Ph.D. Thesis. Furanocoumarins, isopimpinellin and byangelicin were reportedly isolated. Oertli E.H., E. H. Bier, G. W. Ivie, and L. D. Rowe. 1984. Linear furocoumarins and other constituents from Thamnosma texana. Phytochemistry 23: 439–441. “Eight linear furocoumarins were isolated and identified from T. texana. They were xanthotoxin, imperatorin, bergapten, alloimperatorin methyl ether epoxide, heraclenin, isopimpinellin, psoralen and oxypeucedanin. Three coumarins wre identified: herniarin, osthol and thamnosmin. The linear furocoumarins appear to be agents that account for the known photosensitizing properties of T. texana (blisterweed).
Oertli E.H.,
L. D. Rowe, S. L. Lovering, G. W. Ivie and E. M. Bailey. 1983.
Phototoxic effect of Thamnosma texana (Dutchman's breeches) in
sheep. Am. J. Vet. Res. 44(6): 1126–1129. “Oral
exposure of sheep to the airdried, aerial portions of Thamnosma texana
(Dutchman's breeches) resulted in severe photosensitization. Sheep fed the
plant at 9 or 12 g/kg of body weight/day and held in direct sunlight
exhibited signs of phototoxicosis within 24 to 48 hours. The clinical
signs manifested were increased body temperature; photophobia; edema of
the muzzle, ears, and vulva; keratoconjunctivitis with edema of the
cornea; and exudative dermatitis of the skin of the ears, muzzle, and
vulva. Lesser dosages of the plant produced similar effects after several
days, except that corneal edema and opacity were not seen. Histopathologic
studies indicated no hepatic lesions, consistent with primary
photosensitization. The photosensitizing effects of T texana can be
attributed to the presence of photosensitizing linear furocoumarins (psoralens)
in the plant.” |
|
